Dragon begets dragon, phoenix begets phoenix, and the mouse's son can make holes.

Starting from Darwin's theory of evolution, scientists have been studying human genetic material for a long time.

For a long time, everyone believed that the human body had 48 chromosomes. This was the result obtained by a Citizen scientist using the tableting method, but in fact it was wrong.

In fact, chimpanzees have 48 chromosomes, and humans have two fewer chromosomes than them. It is these two chromosomes that cause reproductive isolation between humans and orangutans.

Reproductive isolation is a wonderful thing.

Such as camel.

No matter what kind of camel they are, there is no reproductive isolation between them. Alpacas, dromedary camels, and bactrian camels, although they look very different and are distributed all over the world, they can all intermarry with each other.

The same cannot be said for cattle. For example, buffalo and oxen, although they look similar, are not the same type.

The chromosome number of cattle is 60, while the number of chromosomes of buffalo is 48. Genetically speaking, this cannot be regarded as a species at all.

So what the Asans said is correct. They believe that buffalo is not a cow, only zebu is a cow, zebu is the god they can believe in, and cow urine and cow dung can cure all diseases.

In fact, as far as buffaloes are concerned, the number of chromosomes in river buffaloes is 50, and the number of chromosomes in swamp buffaloes is 48. They can actually hybridize and produce offspring, but the reproductive performance of the hybrid offspring will be reduced.

This is amazing, much more amazing than horses and donkeys. It almost means that mules can also have offspring.

Regarding the number of human chromosomes, it was not until 1956 that Chinese scientist Jiang Youxing concluded after research that the human body has not 48 chromosomes, but 46.

To this end, he took the lead in breaking authoritative judgments and achieving progress in technology and understanding.

Regarding the research on leukemia, a breakthrough came in 1973. Based on the phenomenon and research basis of the Philadelphia chromosome, Janet Rowley proposed an idea: Is all leukemia caused by one chromosome breaking and connecting with another?

It is caused by the connection of a chromosome, thereby exchanging materials and genetic material.

According to this theory, people in this era discovered through research that chronic leukemia is caused by the exchange of genetic material between chromosome 9 and chromosome 22; acute myelogenous leukemia is caused by the mixing of chromosomes 8 and 21; and early childhood leukemia is caused by the mixing of chromosomes 8 and 21.

Granulocytic leukemia has an ambiguous problem between chromosome 15 and chromosome 17.

In short, in all leukemias, part of the gene is lost from the chromosome and stuck to another chromosome.

However, in this era, they did not know how this disease was achieved until Shen Guanglin appeared.

When Shen first decided to develop this drug to treat leukemia, the mainstream scientific community, including Shen Guanglin, had not yet discovered the working mechanism of this disease.

After all, Shen Guanglin studied physics, and biology was indeed a monk halfway through.

In fact, Shen Guanglin doesn't know much about these things, he's just better than the average person.

However, he is reckless.

He immediately asked people to start researching inhibitors of protein kinases, and concluded that this chronic leukemia is caused by a tyrosine kinase. As long as this tyrosine kinase is prevented from continuing to act, the leukemia will be cured.

Already.

Shen Guanglin also said that for conventional tyrosine kinases, their activities are strictly controlled and will not suddenly go out of control.

But the BCR-Abl protein after the lesion is different. It can reproduce indefinitely and produce so-called leukemia, which is blood cancer.

The BCR-Abl protein is not controlled by other molecules and is always active.

This is like locking the accelerator after a cell lesion, causing uncontrolled cell division and causing blood cancer.

Shen Guanglin's conclusion is of course very great, so great that no one dares to believe it or doubt it.

Anyway, his research group skips the process and directly uses the results to take the next step.

Shen Guanglin also said that time waits for no one, and everyone can verify the mechanism while looking for drugs. Anyway, as long as this kind of drug is found, even if it cannot cure leukemia, it will not be a loss.

At least we raised a lot of money.

As we get closer to the 1990s, the attempt to raise money becomes more and more intense.

Where will the Shen Guanglin Laboratory go in the next ten years?

During the time when the compound was discovered, Shen Guanglin went to Jinling for vacation, but his laboratory was not idle.

While he was asking people to test the effects of new drugs, he was also asking people to fill in the working mechanism of the BCR-Abl protein.

It's easier to work backwards from the answers to the problem-solving process.

However, the homework that should be supplemented has not yet been completed, but the new test results have come out.

Professor Shen’s point of view is correct!

Lao Jiang took the leukemia inhibitor code-named 1605, and the effect was remarkable!

Moreover, Shen Guanglin knew in advance that imatinib has a clogging effect on blood vessels, so he directly made an oral medicine, eliminating the trial and error process of injection.

How much money can this save?

Shen Guanglin received a report: After continuous observation by the medical team of Beijing Medical University, since Lao Jiang took 1605, the diseased white blood cells in his body have been completely suppressed, and the effect is surprisingly good!

Almost cured!

Moreover, in Shen Guanglin's view, doctors in this era are really courageous.

No one approved it, and no one discussed it. They talked directly with the family members. This new drug has not yet gone through clinical trials, and they are already using it on other patients.

Do you need to be in such a hurry?

What’s even more amazing is that 1605 not only has a good therapeutic effect on chronic myelogenous leukemia, but also has a good therapeutic effect on other chronic malignant tumors.

For other patients in the oncology department of the hospital, after taking 1605, some patients' symptoms were significantly relieved, and the effects were equally amazing.

It was simply an unexpected surprise.

In fact, if they had not obtained Shen Guanglin's consent, they would have announced that cancer was curable!

In fact, they were still too optimistic.

After hearing the report, Shen Guanglin came to the hospital. The doctors and the patient's family members were very excited.

"Professor Shen, you are a living god. The hope of our whole family lies in you?"

this?

Shen Guanglin looked confused. He still didn't know what happened and why he became a living god.

It turns out that a patient suffered from gastric cancer, a medial tumor, and the treatment effect has been unsatisfactory.

He heard that a new drug being tested was particularly effective in treating leukemia, and he wanted to take it too.

Anyway, he treated a dead horse as a living horse doctor, and the doctor boldly gave him a portion of medicine.

After taking it, the symptoms were greatly relieved, and it is also effective for this disease!

Shen Guanglin said no thank you and continued to walk inside the hospital. He came to see Lao Jiang. Seeing it with his own eyes counts. As for the unexpected surprise, it was an accident. We will talk about it later.

Moreover, 1605 is really not a panacea, it has no effect on many cancers.

Its advantage is that it can inhibit all types of ABL oncogenes. It is indeed not only able to treat leukemia, but it cannot treat other types of diseases.

Shen Guanglin met Lao Jiang and his girl Xiao Jiang after a long absence in the ward.

Lao Jiang looks good. If he were not hospitalized, he would look no different from a normal person.

If it wasn't for continuous observation, he might even want to be discharged from the hospital.

It was obvious that the father and daughter were in a really good mood. Xiao Jiang even said seriously, "I really envy Sister Rongrong for having such a good man."

Shen Guang and Lin Xin said, you can ask Sister Rong to borrow you for one night.

Ten things, is there any?

Shen Guanglin is not a doctor, but everyone still wants to hear his opinion.

What to do next?

Of course I keep eating it!

This medicine cannot be stopped and must be taken continuously.

Moreover, we are trying every day to find out what dose of medicine is suitable for the human body and whether it has any side effects?

All this is unknown, and a large amount of sample data needs to be collected to improve it. The current stage is to continue testing.

Then recruit patients.

There isn't much else in China, it's just that there are a lot of people.

However, in China in this era, people who are sick do not take good care of themselves and often die at home.

Therefore, it is not that easy for Shen Guanglin to recruit patients with chronic myelogenous leukemia.

Some people got chronic myelogenous leukemia, but doctors couldn't diagnose it and their families didn't have money for medical treatment, so the patients died.

Of course, this matter can be left to Pfizer and Takeda. It is difficult to find domestic patients, but international patients are still available.

When Shen Guanglin mentioned this, their spirits immediately rose.

“Has the drug for treating leukemia really been successfully developed?”

Of course it is true. Shen Guanglin gave an affirmative answer. The current preliminary research results show that this drug is effective. The next step is to conduct large-scale human experiments.

Moreover, the case is right in front of you. If you don’t believe it, you can always test the DNA to verify the patient’s actual condition.

After all, a huge amount of money was spent, so it is impossible for them not to pay attention to this matter.

Unable to wait, they immediately sent very professional doctors to check. These people performed a comprehensive physical examination on Lao Jiang as soon as they arrived in China.

Sure enough, it is an abnormality of chromosome 9 and chromosome 22. This is not false.

When they tested Lao Jiang's blood indicators, they clearly found that he was no different from a normal person.

Looking at Lao Jiang's hospitalization records, before he took 1605, his physical condition and various indicators were not satisfactory, but now, he is a completely different person.

Simply amazing!

"Shen, please publish the results quickly. The invention that will shock the world is right in front of you!"
Chapter completed!